Nothing to say here except thanks to DrugMonkey for the heads-up on spotting another case of misconduct causing extensive havoc in the scientific community – this time, Suresh Radhakrishnan, PhD, formerly at the Mayo Clinic Dept of Immunology. No word on whatever formal misconduct investigation may be in progress, but quite a list of affected articles, and some brief insight via the authors’ note to PLoS ONE:
An investigation by the Mayo Clinic has determined that one of the researchers in Professor Pease’s laboratory at the Mayo Clinic, Dr. Suresh Radhakrishnan, tampered with another investigator’s experiment with the intent to mislead toward the conclusion that the B7-DCXAb reagent has cell activating properties. Using blinded protocols, experiments were done to see if the results based on this reagent could be replicated. Specifically, the repeat experiments examined the activation of dendritic cells, activation of cytotoxic T cells, induction of tumor immunity, modulation of allergic responses, breaking tolerance in the RIP-OVA diabetes model, and the reprogramming of Th2 and T regulatory cells. In no case did these repeat studies reveal any evidence that the B7-DCXAb reagent had the previously reported activity. The authors of this paper therefore wish to retract this paper because of the inability to reproduce key aspects of the studies and hence the results in them cannot be considered reliable.
The note in PNAS gives the scope: “In the course of this re-examination, we were able to study all the antibodies used in the various phases of our work spanning the last 10 years. None of these antibodies appears to be active in any of our repeat assays. We do not believe something has happened recently to the reagent changing its potency.”
Retraction: Suresh Radhakrishnan, Esteban Celis, and Larry R. Pease, Proc Natl Acad Sci USA 2005;102:11438–11443
Retraction: Radhakrishnan S, Cabrera R, et al. (2009) PLoS ONE 4(4): e5373
Retraction: Suresh Radhakrishnan, Loc T. Nguyen, Bogoljub Ciric, et al., The Journal of Immunology, 2003, 170: 1830–1838
Retraction: Suresh Radhakrishnan, Koji Iijima, Takao Kobayashi, et al., The Journal of Immunology, 2004, 173: 1360–1365.
Retraction: Suresh Radhakrishnan, Loc T. Nguyen, Bogoljub Ciric, et al., The Journal of Immunology, 2007, 178: 1426–1432.
Retraction: Suresh Radhakrishnan, Karla R. Wiehagen, Vesna Pulko, et al., The Journal of Immunology, 2007, 178: 3583–3592.
Retraction: Suresh Radhakrishnan, Rosalyn Cabrera, Erin L. Schenk, et al., The Journal of Immunology, 2008, 181: 3137–3147.
Retraction: Suresh Radhakrishnan, Laura N. Arneson, Jadee L. Upshaw, et al., The Journal of Immunology, 2008, 181: 7863–7872.
He has other publications and patents that may have some issues as well. Stay tuned.