Notice is hereby given that ORI and the Assistant Secretary for Health have taken final action in the following case:
Based on the report of an investigation conducted by Louisiana State University Health Sciences Center–Shreveport and additional analysis conducted by ORI in its oversight review, the US PHS found that Ryan M. Wolfort, MD, PhD, who was a House Officer in the Department of Surgery, and a former graduate student, Department of Molecular and Cellular Physiology, engaged in research misconduct in the reporting of research supported by grants R01HL26441 and P01HL55552.
Respondent’s research misconduct related to his dissertation research as a graduate student, which he undertook at the same time that he also was serving as a House Officer at LSUHSC-S. ORI acknowledges Dr. Wolfort’s cooperation with the LSUHSC-S misconduct proceedings.
PHS found that Dr. Wolfort engaged in research misconduct by falsifying and fabricating data reported in three publications and one manuscript that had been submitted for publication, reviewed, and returned for revision. Specifically, Dr. Wolfort falsified and fabricated data reported in research examining the contribution of immune mechanisms to early oxidative stress and endothelial dysfunction in mice with induced dietary hypercholesterolemia by:
1. Admittedly fabricating tabulations and the associated statistical analyses of RT-PCR data on Nox-2 mRNA expression in the three publications and the manuscript;
2. Falsifying data and the associated statistical claims, specifically by (a) Admittedly falsifying the measurements of endothelial function by myographic recordings of aortic ring dilation in reaction to vasoactive substances in the three papers and manuscript, (b) admittedly falsifying the measurement of cytokine by cytometric bead assay in paper 3, and (c) falsifying the measurement of superoxide production by cytochrome c reduction in papers 1 and 2, for which the underlying spreadsheet data the Respondent claims were unintentionally misrepresented, massaged, and improperly collated, but for which Respondent acknowledges that the raw data were missing for all three papers, admittedly because he intentionally erased files and discarded notebooks.
[emphasis added …. oof -writedit]