ARRA-Funded Human Immunology Profiling Research Groups

NIAID has released its own ARRA funding opportunity with some unique twists (e.g., 5 years of funding, with only the first year covered by ARRA): Protection of Human Health by Immunology and Vaccines (U01, U19).

LOI due: Sept 15
Application due: Oct 15 (full-length applications – not the 12-p jobs sought by most ARRA FOAs)

For U01 applications, requested annual total costs may not exceed $1.5M in year 1 and $1.3M in years 2-5. For U19 applications, requested annual total costs may not exceed $4.5M in year 1 and $4.0M in years 2-5. NIAID anticipates that 6-10 awards will be made for fiscal year 2010.

NOTE: Recovery Act funds will only support the first budget year of the award, and MUST be completely spent by the end of the first budget year, including spending all Infrastructure and Opportunities Funds allocated to support projects and pilot projects. Award recipients must be prepared to initiate their proposed studies upon issuance of the award. Carryover of unobligated funds from the first to subsequent budget years of the award will NOT be allowed. Any unspent first year funds will be returned. Applicants are encouraged to include in their first year budgets any large, one-time costs to support activities that will be carried out during the project period of the award. Examples of such costs include equipment, large peptide or antibody microarrays, microarray analyses, and small molecule libraries.

All applications are required to use bioinformatic, multiplex, and/or systems biology approaches to establish human immune system profiles using samples from well-characterized cohorts obtained (1) after infection, (2) prior to and following challenge with specific vaccines, or (3) prior to and following treatment with an immune adjuvant that targets a known innate immune receptor(s). It is the goal of this initiative to determine how immune profiles are perturbed and eventually return to a new homeostatic state after antigenic challenge. Each Awardee will establish a research infrastructure to collect, characterize and store human samples, and support the complex statistical analysis and informatics needs of the proposed research. All applications are required to include experimental approaches to measure some aspect(s) of the human transcriptome and/or proteome.

Scientific/Research Contacts:

Dr. Matthew J. Fenton
Division of Allergy, Immunology and Transplantation
Telephone: (301) 496-8973
Email: fentonm@niaid.nih.gov

Dr. Helen R. Quill
Division of Allergy, Immunology and Transplantation
Telephone: (301) 435-4416
Email: hquill@niaid.nih.gov

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