The NIH Challenge Grants have a 12-page application addressing a list of 15 broad challenges due April 27th and allow requests up to $500K/y for 2 years (total of $1M). At least 200 awards will be made. The NIH Challenge Grant Website is now live and loaded, as are the IC-specific Challenge Grant Websites .
The 15 broad challenges are:
(01) Behavior, Behavioral Change, and Prevention
(03) Biomarker Discovery and Validation
(04) Clinical Research
(05) Comparative Effectiveness Research (CER)
(06) Enabling Technologies
(07) Enhancing Clinical Trials
(09) Health Disparities
(10) Information Technology for Processing Health Care Data
(11) Regenerative Medicine
(12) Science, Technology, Engineering and Mathematics Education (STEM)
(13) Smart Biomaterials – Theranostics
(14) Stem Cells
(15) Translational Science
The 12-p research plan instructions follow on the tradition of EUREKA, Pioneer, and T-R01:
Research Area: State which broad Challenge Area (e.g., (01: Behavior, Behavioral Change, and Prevention) described within this FOA and specific Challenge Topic (e.g., Mechanisms of Behavior Change Research: 01-GM-104) will be addressed. Also include the project title on the first page.
The Challenge and Potential Impact: What is the research opportunity, scientific knowledge gap or technology that will be addressed? How broad is the potential impact in science and/or health? Which community (ies) will be affected? What is (are) the size(s) of the community(ies)? Will the potential impact be major?
The Approach: How will you attempt to explore or solve the stated research problem? How will your rationale and/or approach overcome existing challenges or barriers in the field? If you propose to improve existing technologies or to develop new technologies, which needs are being addressed and what is unconventional and exceptionally innovative about your approach? Provide enough information for reviewers to determine what you are proposing to do, but do not include a detailed experimental plan.
Timeline and Milestones: Provide a timeline for the proposed research indicating points where intermediate objectives will be assessed and decisions will be made regarding the course and direction of the continuing research effort. Possible alternative paths that may be followed at critical junctures in the project plan should be described and indicated on the timeline.
Preliminary data are not required but may be included, if necessary to demonstrate the feasibility of the proposed studies. The presentation must be clear and particularly compelling. No detailed scientific plan should be provided, but timelines must be presented.
No appendices and no post-submission supplemental material/updates are permitted.
Also, per the RFA, “Because the awards made under this program are substantial competing NIH research grants, recipients will not be considered New PIs or ESIs when they apply for NIH research grants in the future.” Ready to sign away your new/early stage investigator status for a million bucks over two years? My guess is yes.