Notice is hereby given that the Office of Research Integrity and the Acting Assistant Secretary for Health have taken final action in the following case:
Lois Bartsch, PhD, former postdoctoral research trainee, Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, engaged in scientific misconduct in research supported by grants P30 CA36727, R01 CA77876, and P20 RR016469. Specifically, PHS found that Dr. Bartsch:
Falsified DNA sequence files by deleting a nucleotide and changing nucleotide designations and reported the altered file as the ACI rat p16Cdkn2a sequence with a CpG dinucleotide polymorphism in the upstream region to GenBank, in grant application CA118151, and in the poster presented to Cold Spring Harbor Laboratory;
Fabricated the claim in grant application CA118151 that GenBank entries for the human p16Cdkn2a gene had a CpG polymorphism near the transcription start site;
Falsified the differential methylation of CpG dinucleotides near the transcription start site of p16Cdkn2a DNA and reported that tumor tissue was more methylated than normal tissue in ACI rats treated with estrogen and that the ACI allele was more methylated than the BN allele in tumor tissue from (BN x ACI)F1 animals treated with estrogen in grant application CA118151.