Exceptional, Unconventional Research Enabling Knowledge Acceleration … an RFA co-sponsored by NIGMS, NIDA, NIMH, NINDS, and NIAID to provide non-renewable R01 support to “investigators who are testing novel, unconventional hypotheses or are pursuing major methodological or technical challenges. … Several key features of the EUREKA FOA have been designed to emphasize to applicants and peer reviewers that these applications are very different from conventional, investigator-initiated R01s.” So – read the RFA carefully, and then read very carefully between the lines. LOI due Sept 24th, application receipt date is Oct 24th.



  1. whimple said

    What do you think the writing between the lines says?

  2. PhysioProf said

    These things will be harder to get than an R01, and have significant disavantages: less money than a maxed-out modular R01, shorter duration than a maxed-out modular R01, no competitive renewal, and no possibility for a resubmission to improve the score. I am also skeptical that reviewers will be able to be induced to not give a lot of weight to preliminary data.

  3. writedit said

    We’ll see if the award restrictions convince applicants to use the mechanism as intended (a longer, better funded R21 substitute) and whether reviewers can be convinced to critique them accordingly. No preliminary data, no appendices, no real methods, 10 annotated pubs per PI bio, and only 1 page of lit cited will present a challenge for traditional reviewers, as will the quirky 8-page, jargon-free, general science essay. Sounds like they might do better with judges from the Intel Science Talent Search or the Siemens Math, Science & Technology Competition.

    I would certainly recommend early and regular communication with the appropriate program officer for your application, including a review of your hypothesis/proposed methodology to be developed (no specific aims for these proposals) and the anticipated impact. I would push for specific comments as to whether your “challenge” and your approach are in line with the program officers’ vision of the RFA, since they’ll be the ones providing guidance on review criteria to the SRAs and reveiw panels. They clearly have envisioned specific types of applications in developing this mechanism, and that is what they need to fill in for you between the limited lines of the RFA announcement itself.

  4. writedit said

    EUREKA awardees announced

    September 2008

    National Institute of General Medical Sciences

    John Chaput, Arizona State University, Tempe
    “Discovering a Hidden Proteome in the Human Genome”

    Daniel T. Chiu, University of Washington
    “Super-Resolution Imaging with Difference Deconvolution Microscopy”

    Tanja Dominko, Worcester Polytechnic Institute
    “De-Differentiating Adult Human Fibroblasts into Stem-Like Cells Using Defined Conditions”

    Iswar K. Hariharan, University of California, Berkeley
    “Identifying Novel Strategies to Promote Tissue Regeneration”

    James M. Hogle, Harvard University Medical School
    “Correlative Cyro-Miscroscopy: A New Approach for Characterizing the Structure and Function of Intracellular Macromolecular Machines in Situ”

    Laurence H. Hurley, University of Arizona, Tucson
    “Establishing a Molecular System for Drug Targeting of Transcriptional Control”

    Masayori Inouye, University of Medicine & Dentistry of New Jersey/Robert Wood Johnson Medical School
    “The Method for Determination of Membrane Protein Structures Without Purification”

    Michelle Krogsgaard, New York University School of Medicine
    “Visualizing Ligand-Induced Signal Propagation in the TCR-Signaling Complex”

    Jeanne B. Lawrence, University of Massachusetts Medical School, Worcester
    “Is Chromosome Therapy Possible for Down Syndrome and Other Karyotypic Imbalances?”

    Joseph A. Loo, University of California, Los Angeles
    “Impact of Non-Canonical Decoding on the Proteome”

    Lee Makowski, University of Chicago
    “MADMAX: Precise Measurement of Conformational Changes in Proteins”

    Scott R. Manalis, Massachusetts Institute of Technology
    “High-Throughput Monitoring of Mass, Density, and Fluorescence of Single Cells”

    William E. Moerner, Stanford University
    “Three-Dimensional Super-Resolution Imaging in Living Cells Using Single-Molecule Active Control”

    John W. Sedat, University of California, San Francisco
    “Enabling High-Resolution Imaging Deep in Live Tissue with Adaptive Optics”

    David F. Smith, Emory University
    “Shotgun Glycomics: Linking Glycan Structure and Function”

    Charles E. Stebbins, Rockefeller University
    “Exploiting a Bacterial Nano-Syringe for Protein Therapeutics”

    Michael H. Stowell, University of Colorado at Boulder
    “Self Assembled Lipid Icosohedra for High-Throughput Membrane Protein Structure Determination”

    Brian D. Strahl, University of North Carolina, Chapel Hill
    “A High-Throughput Approach Towards Deciphering the Histone Code”

    Russell N. Van Gelder, University of Washington Medical Center, Seattle
    “Mechanisms of Light-Mediated Protein Degradation”

    Alexander J. Varshavsky, California Institute of Technology
    “Split Proteins as Boolean Circuits and Drugs of a New Kind”

    National Institute of Neurological Diseases and Stroke

    Karen Ashe, University of Minnesota, Twin Cities
    “In Search of the Molecular Basis of Memory Loss in Tauopathy”

    Akira Chiba, University of Miami, Coral Gables
    “Mechanical Force and Neural Regeneration”

    Janis J. Daly, Case Western Reserve University
    “Non-Invasive Brain-Signal Training to Induce Motor Control Recovery After Stroke”

    Beverly Davidson, University of Iowa
    “RNA Aptamers for Brain Delivery”

    David Sretavan, University of California, San Francisco
    “Microscale Axon Repair as a Novel Paradigm for Nerve Injuries”

    National Institute of Mental Health

    Paul Brehm, Oregon Health & Science University
    “A Genetic Indicator Provides Long Term Mapping of Neuronal and Calcium Activity”

    David Kleinfeld, University of California, San Diego
    “Neuronal Signaling, Network Topology, and Blood Flow Dynamics in Cortex”

    Todd Lencz, Feinstein Institute for Medical Research
    “Identifying Molecular Subtypes of Schizophrenia: A Novel Genomic Approach”

    Rick C.S. Lin, University of Mississippi Medical Center
    “Serotonin, Corpus Callosum, and Autism”

    Joshua Ahab Maurer, Washington University in St. Louis
    “Unraveling Development: New Materials for Understanding Neuronal Wiring”

    Andras Jagy and Hongkui Zeng, Allen Institute for Brain Science
    “Generation and Characterization of Novel and Highly Specific Neuronal Subtype TRA”

    Bernardo L. Sabatini, Harvard University Medical School
    “Regulation of Neuron and Synapse Function by Neuropeptides”

    Yi Eve Sun, University of California, Los Angeles
    “A Novel Approach to Identify Neuronal mRNA Targets for Individual microRNAs”

    Michael J. Tarr, Brown University
    “Using Functional Physiology to Uncover the Fundamental Principles of Visual Cortex”

    National Institute on Drug Abuse

    Jeff W. Bulte, Johns Hopkins University
    “Developing MPI for Non-Invasive and Quantitative Imaging of Stem Cells”

    Benjamin F. Cravatt, Scripps Research Institute
    “Toward a Potent and Selective Inhibitor for Every Mammalian Serine Hydrolase”

    Rodolfo E. Diaz, Arizona State University, Tempe
    “Feasibility Demonstration of an Artificial Electrocyte for Neuronal Observation & Stimulation”

    Emad N. Eskandar, Massachusetts General Hospital
    “Striatal Deep Brain Stimulation for Learning Enhancement”

  5. whimple said

    It all sounds like crap to me, but what do I know? 🙂

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