<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	>
<channel>
	<title>Comments for Medical Writing, Editing &amp; Grantsmanship</title>
	<atom:link href="http://writedit.wordpress.com/comments/feed/" rel="self" type="application/rss+xml" />
	<link>http://writedit.wordpress.com</link>
	<description>Customized Customer Support for Biomedical Researchers</description>
	<pubDate>Fri, 04 Jul 2008 07:25:16 +0000</pubDate>
	<generator>http://wordpress.org/?v=MU</generator>
		<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by noblesse d'epee</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4227</link>
		<dc:creator>noblesse d'epee</dc:creator>
		<pubDate>Thu, 03 Jul 2008 20:10:40 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4227</guid>
		<description>The notarized page was dated yesterday, 2nd July. The signatures were gathered in the preceding week. I am told that the petition was delivered to the last of its recipients' offices by mid-day today.</description>
		<content:encoded><![CDATA[<p>The notarized page was dated yesterday, 2nd July. The signatures were gathered in the preceding week. I am told that the petition was delivered to the last of its recipients&#8217; offices by mid-day today.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by scotus</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4226</link>
		<dc:creator>scotus</dc:creator>
		<pubDate>Thu, 03 Jul 2008 19:32:09 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4226</guid>
		<description>Writedit- 
The RDU population is pretty savvy when it comes to matters relating to higher education and research.  Besides, this story has a lot going for it..money, fame, abuse of power, intrigue, scandal and an opportunity to put the boot into Duke University which is generally not well-liked by the locals (as established by the intial phases of the Lacrosse Case).  You’re right, the science could be a bit dry but at the core this is a morality tale.   I bet a good journalist could write a story that would capture the interest of the readership of the local press.</description>
		<content:encoded><![CDATA[<p>Writedit-<br />
The RDU population is pretty savvy when it comes to matters relating to higher education and research.  Besides, this story has a lot going for it..money, fame, abuse of power, intrigue, scandal and an opportunity to put the boot into Duke University which is generally not well-liked by the locals (as established by the intial phases of the Lacrosse Case).  You’re right, the science could be a bit dry but at the core this is a morality tale.   I bet a good journalist could write a story that would capture the interest of the readership of the local press.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by scotus</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4225</link>
		<dc:creator>scotus</dc:creator>
		<pubDate>Thu, 03 Jul 2008 18:49:34 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4225</guid>
		<description>The only individuals who would "benefit" from making the matter go away would be those who may have done something that could be exposed by an investigation.

My understanding of the "case" so far is that Hellinga made an allegation of misconduct against Dwyer pertaining specifically to the Novo-TIM expression/purification/kinetics experiments and that this allegation was not sustained by the initial investigation.  However, we don't know the details of why the allegation was not sustained and can only infer that Dwyer was not found to have done anything that was grounds for a formal investigation.

As I understand the process, as a condition of their acceptance of federal funding Duke would be compelled to investigate any reasonable and credible allegation of research misconduct made against any of their employees. I would think that the very public statments documenting the insufficiency of the Hellinga-Dwyer retractions would constitute grounds for another initial investigation focussing on issues that were apparently unresolved or un touched upon by the original investigation of Dwyer.  

Duke are now in a bit of a bind.  On the one hand, an investigation of Hellinga seems inevitable if not already ongoing.  On the other hand as I have said repeatedly, Hellinga is probably entitled (as was Dwyer) to have the intial investigation treated confidentially.  Unfortunately by not commenting on the matter Duke are creating the perception that nothing is being done.  

The petition is not dated?  When was it submitted?  My best guess is that Duke will respond in a week or so with some more lukeward assurances that they are aware of these concerns but will not comment further on the matter to preserve the confidentiality of everyone involved.  

Has this matter been picked up on by the local press?  The more widely-known it becomes, the harder it will be for Duke to sweep it under the table.

&lt;em&gt;The dating would be done on the signature pages and via the notary. I believe the petition had just recently been submitted when I posted it. Local press coverage wouldn't be as meaningful as national media or academic publications such as The Chronicle of Higher Education. On the other hand, local coverage could lead to the story getting picked up nationally. Still, it's a tough story to sell in an elevator speech, especially for a lay audience, unless you focus on behavior rather than science. - writedit&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>The only individuals who would &#8220;benefit&#8221; from making the matter go away would be those who may have done something that could be exposed by an investigation.</p>
<p>My understanding of the &#8220;case&#8221; so far is that Hellinga made an allegation of misconduct against Dwyer pertaining specifically to the Novo-TIM expression/purification/kinetics experiments and that this allegation was not sustained by the initial investigation.  However, we don&#8217;t know the details of why the allegation was not sustained and can only infer that Dwyer was not found to have done anything that was grounds for a formal investigation.</p>
<p>As I understand the process, as a condition of their acceptance of federal funding Duke would be compelled to investigate any reasonable and credible allegation of research misconduct made against any of their employees. I would think that the very public statments documenting the insufficiency of the Hellinga-Dwyer retractions would constitute grounds for another initial investigation focussing on issues that were apparently unresolved or un touched upon by the original investigation of Dwyer.  </p>
<p>Duke are now in a bit of a bind.  On the one hand, an investigation of Hellinga seems inevitable if not already ongoing.  On the other hand as I have said repeatedly, Hellinga is probably entitled (as was Dwyer) to have the intial investigation treated confidentially.  Unfortunately by not commenting on the matter Duke are creating the perception that nothing is being done.  </p>
<p>The petition is not dated?  When was it submitted?  My best guess is that Duke will respond in a week or so with some more lukeward assurances that they are aware of these concerns but will not comment further on the matter to preserve the confidentiality of everyone involved.  </p>
<p>Has this matter been picked up on by the local press?  The more widely-known it becomes, the harder it will be for Duke to sweep it under the table.</p>
<p><em>The dating would be done on the signature pages and via the notary. I believe the petition had just recently been submitted when I posted it. Local press coverage wouldn&#8217;t be as meaningful as national media or academic publications such as The Chronicle of Higher Education. On the other hand, local coverage could lead to the story getting picked up nationally. Still, it&#8217;s a tough story to sell in an elevator speech, especially for a lay audience, unless you focus on behavior rather than science. - writedit</em></p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by George Smiley</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4224</link>
		<dc:creator>George Smiley</dc:creator>
		<pubDate>Thu, 03 Jul 2008 18:26:02 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4224</guid>
		<description>Noblesse, I respectfully disagree. Depending on what actually occurred here, one or more of the parties you mention may benefit quite substantially by leaving this matter unresolved. Kudos to the students at Duke for pursuing this. I sure would not want to be the acting Chair at this moment, though.</description>
		<content:encoded><![CDATA[<p>Noblesse, I respectfully disagree. Depending on what actually occurred here, one or more of the parties you mention may benefit quite substantially by leaving this matter unresolved. Kudos to the students at Duke for pursuing this. I sure would not want to be the acting Chair at this moment, though.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by noblesse d'epee</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4222</link>
		<dc:creator>noblesse d'epee</dc:creator>
		<pubDate>Thu, 03 Jul 2008 15:54:04 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4222</guid>
		<description>Scotus,

Thanks for your insights and commentary.  At this point, given the obvious gaps in Homme's scientific explanations coupled and the ethical issues raised in the published analyses of this scandal, I think that it is perfectly reasonable for students other than Dwyer to request a misconduct investigation. In fact, considering the faculty's apparent inaction, doing so is arguably students' obligation to their (former) peer, to their graduate program, and to their field. Neither Hellinga, nor Dwyer, nor Duke Biochem. benefit from leaving this issue unresolved.</description>
		<content:encoded><![CDATA[<p>Scotus,</p>
<p>Thanks for your insights and commentary.  At this point, given the obvious gaps in Homme&#8217;s scientific explanations coupled and the ethical issues raised in the published analyses of this scandal, I think that it is perfectly reasonable for students other than Dwyer to request a misconduct investigation. In fact, considering the faculty&#8217;s apparent inaction, doing so is arguably students&#8217; obligation to their (former) peer, to their graduate program, and to their field. Neither Hellinga, nor Dwyer, nor Duke Biochem. benefit from leaving this issue unresolved.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by scotus</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4221</link>
		<dc:creator>scotus</dc:creator>
		<pubDate>Thu, 03 Jul 2008 15:23:39 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4221</guid>
		<description>In essense, this is an allegation of research misconduct against Hellinga.  Unfortunately its an allegation "by proxy" because none of the petitioners have first hand knowledge of of the "facts" of the Dwyer-Hellinga interactions that led to Hellinga's alleged misconduct.  On the other hand, the very unique public nature of this affair demands that Duke address what the petitioners note as the concerns of eminent biochemists "that the Hellinga-Dwyer retractions are insufficient to explain the manner in which Hellinga and Dwyer arrived at their erroneous conclusions".  As I have said before, if Duke are not already conducting an investigation into the "insufficiency" of Hellinga's explanation then this petition ought to prompt them to do so.  If they are already investigating the issue then I hope Duke's  response to the petition will be to make the existence of this investigation public despite what I am certain will be very strong opposition from Hellinga and his counsel.</description>
		<content:encoded><![CDATA[<p>In essense, this is an allegation of research misconduct against Hellinga.  Unfortunately its an allegation &#8220;by proxy&#8221; because none of the petitioners have first hand knowledge of of the &#8220;facts&#8221; of the Dwyer-Hellinga interactions that led to Hellinga&#8217;s alleged misconduct.  On the other hand, the very unique public nature of this affair demands that Duke address what the petitioners note as the concerns of eminent biochemists &#8220;that the Hellinga-Dwyer retractions are insufficient to explain the manner in which Hellinga and Dwyer arrived at their erroneous conclusions&#8221;.  As I have said before, if Duke are not already conducting an investigation into the &#8220;insufficiency&#8221; of Hellinga&#8217;s explanation then this petition ought to prompt them to do so.  If they are already investigating the issue then I hope Duke&#8217;s  response to the petition will be to make the existence of this investigation public despite what I am certain will be very strong opposition from Hellinga and his counsel.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by noblesse d'epee</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4220</link>
		<dc:creator>noblesse d'epee</dc:creator>
		<pubDate>Thu, 03 Jul 2008 11:11:37 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4220</guid>
		<description>I am told that the signers totaled 18, of which 17 are current Duke Biochem. students (mostly senior, e.g. Ph.D. candidates) and one recent alumnus.  My understanding is that current students (as opposed to alumni) were sought by the petition's authors because:

1. There arose logistical inpracticalities in the gathering of alumni signatures
2. Graduate students theoretically had the most to lose by signing, thus their position carried more significance that that of alumni

It is important to mention that this was a completely student-led effort. Professors were not asked to sign the petition, nor was it circulated among them. The signers of the petition did NOT sign as proxies for their laboratories or PI's. 

I am told that the petition was written and distributed without the knowledge of Mary Dwyer. It seems that scrupulous efforts were made by the signers to avoid Dwyer while the petition was circulating.

There are ~55 students currently in the Duke Biochem. Dept. If one subtracts the Hellinga graduate students, Hellinga's wife Lorena Beese's students, and students who have either of those professors on their thesis committees, ~45 eligible students remain. So 18 represents close to 1/3 of the eligible population. I am told that few students without Ph.D. candidacy signed the petition. If one substracts students who have not taken their candidacy exams from the pool of eligible signers, the petiton represents ~1/2 of the remaining students. 

In my opinion, a majority "vote" of students was in no way required to add legitimacy to the petition. That 18 current students were willing to sign was unexpected, and was an indication of the bravery and ethical conviction of our program's student community.

A final note: I did not provide WriteEdit with a copy of the petition, although I am not unhappy to see it published on this blog.

&lt;em&gt;I will confirm that noblesse d'epee did not send me the petition, but I appreciate these additional details. Again, I am so very impressed with these students and their decision to act on their convictions. One would hope the faculty will independently register their concern with the administration in solidarity with the students. - writedit&lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>I am told that the signers totaled 18, of which 17 are current Duke Biochem. students (mostly senior, e.g. Ph.D. candidates) and one recent alumnus.  My understanding is that current students (as opposed to alumni) were sought by the petition&#8217;s authors because:</p>
<p>1. There arose logistical inpracticalities in the gathering of alumni signatures<br />
2. Graduate students theoretically had the most to lose by signing, thus their position carried more significance that that of alumni</p>
<p>It is important to mention that this was a completely student-led effort. Professors were not asked to sign the petition, nor was it circulated among them. The signers of the petition did NOT sign as proxies for their laboratories or PI&#8217;s. </p>
<p>I am told that the petition was written and distributed without the knowledge of Mary Dwyer. It seems that scrupulous efforts were made by the signers to avoid Dwyer while the petition was circulating.</p>
<p>There are ~55 students currently in the Duke Biochem. Dept. If one subtracts the Hellinga graduate students, Hellinga&#8217;s wife Lorena Beese&#8217;s students, and students who have either of those professors on their thesis committees, ~45 eligible students remain. So 18 represents close to 1/3 of the eligible population. I am told that few students without Ph.D. candidacy signed the petition. If one substracts students who have not taken their candidacy exams from the pool of eligible signers, the petiton represents ~1/2 of the remaining students. </p>
<p>In my opinion, a majority &#8220;vote&#8221; of students was in no way required to add legitimacy to the petition. That 18 current students were willing to sign was unexpected, and was an indication of the bravery and ethical conviction of our program&#8217;s student community.</p>
<p>A final note: I did not provide WriteEdit with a copy of the petition, although I am not unhappy to see it published on this blog.</p>
<p><em>I will confirm that noblesse d&#8217;epee did not send me the petition, but I appreciate these additional details. Again, I am so very impressed with these students and their decision to act on their convictions. One would hope the faculty will independently register their concern with the administration in solidarity with the students. - writedit</em></p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by whimple</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4219</link>
		<dc:creator>whimple</dc:creator>
		<pubDate>Thu, 03 Jul 2008 03:01:30 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4219</guid>
		<description>Did any professors of Biochemistry at Duke sign the petition?

&lt;em&gt;That I don't know: I did not receive any of the names/signatures involved. If someone lets me know off-line, I can post whether faculty lent their support as well. It sounds like a student-led initiative, which is quite gutsy since I suspect many must have Hellinga or his wife on their committees. On the other hand, the students are also the ones who will pay the greatest price if Duke does not act, so have significant motivation for making their collective voice heard (faculty should be quite concerned about the potential misconduct, of course, but do not have to interact with the parties under discussion in order to secure their degrees ... and such turning a blind eye seems more common than we all thought per the &lt;a href="http://writedit.wordpress.com/2008/06/19/nature-on-misconduct-2/" rel="nofollow"&gt;ORI report&lt;/a&gt;). &lt;/em&gt;</description>
		<content:encoded><![CDATA[<p>Did any professors of Biochemistry at Duke sign the petition?</p>
<p><em>That I don&#8217;t know: I did not receive any of the names/signatures involved. If someone lets me know off-line, I can post whether faculty lent their support as well. It sounds like a student-led initiative, which is quite gutsy since I suspect many must have Hellinga or his wife on their committees. On the other hand, the students are also the ones who will pay the greatest price if Duke does not act, so have significant motivation for making their collective voice heard (faculty should be quite concerned about the potential misconduct, of course, but do not have to interact with the parties under discussion in order to secure their degrees &#8230; and such turning a blind eye seems more common than we all thought per the <a href="http://writedit.wordpress.com/2008/06/19/nature-on-misconduct-2/" rel="nofollow">ORI report</a>). </em></p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Cont&#8217;d Hellinga Fall-Out (May 2008) by writedit</title>
		<link>http://writedit.wordpress.com/2008/05/14/contd-hellinga-fall-out-may-2008/#comment-4217</link>
		<dc:creator>writedit</dc:creator>
		<pubDate>Wed, 02 Jul 2008 22:20:15 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=445#comment-4217</guid>
		<description>I was sent a &lt;a href="http://writedit.wordpress.com/files/2008/06/duke_hellinga_petition.pdf" rel="nofollow"&gt;petition&lt;/a&gt; that was circulated among all graduate students in the &lt;a href="http://ives.biochem.duke.edu/" rel="nofollow"&gt;Department of Biochemistry&lt;/a&gt; at the Duke University School of Medicine and signed by nearly half of them representing about a dozen labs. Notarized copies of the signed petition have been delivered to the Interim Chair of Biochemistry and the Dean of the School of Medicine, among others (see list in &lt;a href="http://writedit.wordpress.com/files/2008/06/duke_hellinga_petition.pdf" rel="nofollow"&gt;petition&lt;/a&gt; itself - please note, student names and signatures are NOT included). 

As you will see, the petition asks "that Duke University determine whether Professor Homme W. Hellinga:



&lt;blockquote&gt;1. Published Dr. Mary Dwyer’s data, despite her objections, with the effect of "manipulating research procedures and data so as to bias results"

2. Pursued "baseless and malicious, or reckless" research misconduct charges against Dr. Dwyer"&lt;/blockquote&gt;



Hats off to these students and the stand they have taken here.</description>
		<content:encoded><![CDATA[<p>I was sent a <a href="http://writedit.wordpress.com/files/2008/06/duke_hellinga_petition.pdf" rel="nofollow">petition</a> that was circulated among all graduate students in the <a href="http://ives.biochem.duke.edu/" rel="nofollow">Department of Biochemistry</a> at the Duke University School of Medicine and signed by nearly half of them representing about a dozen labs. Notarized copies of the signed petition have been delivered to the Interim Chair of Biochemistry and the Dean of the School of Medicine, among others (see list in <a href="http://writedit.wordpress.com/files/2008/06/duke_hellinga_petition.pdf" rel="nofollow">petition</a> itself - please note, student names and signatures are NOT included). </p>
<p>As you will see, the petition asks &#8220;that Duke University determine whether Professor Homme W. Hellinga:</p>
<blockquote><p>1. Published Dr. Mary Dwyer’s data, despite her objections, with the effect of &#8220;manipulating research procedures and data so as to bias results&#8221;</p>
<p>2. Pursued &#8220;baseless and malicious, or reckless&#8221; research misconduct charges against Dr. Dwyer&#8221;</p></blockquote>
<p>Hats off to these students and the stand they have taken here.</p>
]]></content:encoded>
	</item>
	<item>
		<title>Comment on Supplemental Funding 2008 - and FY09 Budget Projections by drugmonkey</title>
		<link>http://writedit.wordpress.com/2008/07/01/supplemental-funding-2008-and-fy09-budget-projections/#comment-4214</link>
		<dc:creator>drugmonkey</dc:creator>
		<pubDate>Wed, 02 Jul 2008 20:02:09 +0000</pubDate>
		<guid isPermaLink="false">http://writedit.wordpress.com/?p=485#comment-4214</guid>
		<description>&lt;em&gt;Yeah, running my laboratory is just a hobby! LOLZ!&lt;/em&gt;

yes but what if breaking down the right wing wackaloon theocratic hegemony for a generation through blogging were to work?</description>
		<content:encoded><![CDATA[<p><em>Yeah, running my laboratory is just a hobby! LOLZ!</em></p>
<p>yes but what if breaking down the right wing wackaloon theocratic hegemony for a generation through blogging were to work?</p>
]]></content:encoded>
	</item>
</channel>
</rss>
