Archive for April, 2009

Grants that Work for Women

Just think if instead of studying why women do or do not succeed in biomedical research careers or what intervention is needed, the NIH simply provided funds that addressed the “pitfalls” of a life of science. Sort of like the Elsevier Foundation currently does with their New Scholar program. Nature features this refreshingly straightforward approach to helping women succeed as researchers, including the “research” that went into setting up this program:

David Ruth, foundation executive director, says the grants’ focus on childcare, family issues and career advancement grew out of discussions with organizations and agencies internationally, all of which identified early- to mid-career women scientists as most likely to leave the field. They found that concerns about work-life balance were a central reason for the exodus. Ruth says the foundation is trying to spur the development of new programmes to address these conflicts, in hopes of reducing the dropout rate.

I bet it didn’t require a multi-million dollar budget either.

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Latest ARRA Opportunities

Both of today’s RFAs target specialized applicants.

The Academic Research Enhancement Award (R15) seeks to help institutions that are “otherwise unlikely to participate extensively in NIH programs” (i.e., have not received more than $6 million per year in total costs from the NIH in 4 or more of the past 7 years). These 12-p ditties are due Sept 24 (no LOI) and are worth up to $300,000 in total costs over a project period lasting up to 3 years. Each participating IC has a designated contact person. The NIH maintains a nice AREA Resource page to help applicants.

At the other end of the scale, NCRR’s Enabling National Networking of Scientists and Resource Discovery (U24) targets an even more exclusive and elite club: institutions who hold current NCRR Center and Center-like Programs (e.g., CTSA, RTRN, BIRN, BRTC, ABMR, NPRC) as well as the AREA-like center mechanisms (e.g., COBRE, INBRE, RCMI). NCRR will fund 2 awards of $15,000,000 total costs over a 2-year project period. Now, each application must involve a minimum of 6 institutions with one of the eligible NCRR center/center-like awards. Research plan goes for 40 pages and is due June 15; optional though recommended LOI is due May 18 (just the usual info – no mini pre-proposal in the LOI as suggested for RC2s). They’re looking for Web-based tools & infrastructure to make researchers everywhere aware of available resources and to make these resources accessible. NCRR’s preference is for “distributed or federated approaches to both research networking and resource discovery with local control of information sources.” Can’t wait to see how all these egos cram into one proposal and come to consensus on the lead applicant.

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Challenging Grand Opportunities

No rest for the weary. Grand Opportunity letters of intent are due Monday, April 27 to the appropriate GO PO.

Please note the request for a lot more detail than is typical in an LOI. In fact, they essentially want most of the proposal, including its budget.

Prospective applicants are asked to submit a LOI that includes the following information:

  • Descriptive title of proposed research.
  • Name, address, and telephone number of the PD(s)/PI(s).
  • Names of other key personnel.
  • Participating institutions.
  • Number and title of this funding opportunity.

Sounds familiar so far. But prospective applicants are also asked to consider including [translation: damn well better include] the following in the LOI:

  • Description of the research areas, including any subprojects
  • Significance of the proposed research
  • Rationale why the application is not suitable for the Challenge Grant program
  • Evidence that the project is ready for immediate implementation
  • Key personnel
  • Direct, contract F&A, and total costs for each year
  • Description of how the goal and outcomes of the project match the goals of the ”GO” grants program and Recovery Act
  • Preliminary list of the expected 2-year outcomes and deliverables.

This last bit is really important. NIH needs to have a lot to show Congress at the end of 2 years for its $10B stimulus funding, particularly this grand opportunity to support “large-scale research projects that have a high likelihood of enabling growth and investment in biomedical research and development, public health and health care delivery.” Is that all?

Remember that not all ICs are participating (i.e., FIC, NCRR, NEI, NIAID, NIDCD, NIDDK, NLM), and most of those who are have explicit lists of funding priorites – although some simply ask applicants to address the IC’s published priorities (e.g., NINDS). I suspect these LOIs will be especially critical for ICs in this latter category.

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Challenge Grant Review Process & Timeline

Update: CSR has confirmed in the May Peer Review Notes that they will use the 2-phase editorial board approach for the RC1s, as noted in the comment below.

NIH has posted a tentative timeline for the Challenge Grant review process, which will likely follow the Transformative path of a two-stage editorial board review (so assume Stage 1 reviews completed in June, probably via IAR, with editorial boards discussing applications in July):

NIH is using an innovative peer review format—editorial board reviews—to help identify research that has the potential to transform biomedicine. Two groups of reviewers play key roles: specialized experts assess the applications for scientific merit and submit written critiques; experienced reviewers with a broad understanding of the science further critique the applications. This second group functions as the editorial board and meets face-to-face or electronically to discuss the initial assessments and score the applications by focusing on their overall significance and impact.

CSR is using this type of review to assess new Transformative R01 applications in an effort to support extraordinarily innovative, high-risk, original or unconventional research projects that hold promise to revolutionize a broad area of biomedical or behavioral research: http://nihroadmap.nih.gov/T-R01/. Editorial board reviewers will conduct an initial review and select a reasonable number for further review.

CSR initiated an evaluation of the quality and effectiveness of editorial board reviews in spring 2008. The pilot involved a range of SBIR (Small Business Innovation Research) and Bioengineering Research Partnership applications. Preliminary data show that editorial board reviews may improve the quality of reviews for complex, multidisciplinary applications.

A majority of reviewers, some 64%, said they would choose this type of review for their own applications; of the experts who submitted written critiques considered by the editorial boards, about 38% said they would prefer these reviews for their own applications.

No matter what, you’ll receive back critiques and criteria scores (and an impact score if your application is “discussed”), which will be useful for converting RC1s into R21s or R01s as appropriate … or not if the comments and scores suggest you not pursue this line of work.

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Naturally Obsessed: the making of a scientist

Naturally Obsessed is a one-hour documentary by Richard and Carole Rifkind that can be booked for screening (no cost to attendees) at your very own institution ($165 for non-profits, $300 for others). Per the film’s slick Website, the documentary involved 3 years of filming as it followed a group of “irrepressible graduate students working towards the PhD degree, and their mentor, a tough but genial young professor.” You can all take a break from overstimulated grant writing to dream about who would portray you in the major motion picture of your own training experience …

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Findings of Scientific Misconduct

Oof. A fellowship director no less. Comment below provides “the rest of the story.”

Notice is hereby given that ORI and the Assistant Secretary for Health have taken final action in the following case:

Based on information that the Respondent volunteered to his former mentor on November 7, 2006, and detailed in a written admission on September 19, 2007, and ORI’s review of Joint Inquiry and Investigation reports by Harvard Medical School (HMS) and the Brigham and Women’s Hospital (BWH), the US PHS found that Dr. Robert B. Fogel, former Assistant Professor of Medicine and Associate Physician at HMS, and former Co-Director of the Fellowship in Sleep Medicine at BWH, engaged in scientific misconduct in research supported by awards P50HL60292, R01HL48531, K23HL04400, F32HL10246, and M01RR02635 [GCRC-writedit].

PHS found that Respondent engaged in scientific misconduct by falsifying and fabricating baseline data published in Fogel,RB et al. Anatomic and physiologic predictors of apnea severity in morbidly obese subjects. Sleep 2003;2:150-155 and in a preliminary abstract reporting on this work. Specifically, PHS found that for the data reported in the Sleep paper, the Respondent:

  • Changed/falsified roughly half of the physiologic data
  • Fabricated roughly 20% of the anatomic data that were supposedly obtained from CT images
  • Changed/falsified 50-80% of the other anatomic data
  • Changed/falsified roughly 40-50% of the sleep data so that those data would better conform to his hypothesis.
  • Respondent also published some of the falsified and fabricated data in an abstract in Sleep 24, Abstract Supplement A7, 2001.

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And the Next CTSA Winner is …

the University of Cincinnati, as announced by the NIH today.

This brings the number of funded sites up to 39, with 21 awards left to distribute. Quite a number of applications were reviewed this past February (two large SEPs convened on Feb 10 and Feb 18 to examine them) in competition for 5 awards (assuming UCinn took one of the 6 from the last RFA’s 2 submission dates), and the current RFA (submission date of Oct ) will award 4 sites. Nice to see they plan to continue a more gradual distribution of the remaining sites, no doubt JIT for competing renewals of the current awardees.

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Day 61 in the Obama Administration (ARRA job tracking explained)

So now we know how they’re tracking the economic stimulus data … from America’s Finest News Source (The Onion):

DAY 61: Chris Dillard of Bethesda, MD, receives the first new job under Obama’s stimulus plan, being tasked with flipping the numbers on the White House scoreboard every time a new job is created.

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New NIH Review Guidelines & Videos

JIT for their implementation of the new review and scoring procedures, the NIH has posted guidelines for study section reviewers and chairs as well as guidelines and critique templates for various grant mechanisms.

You can also view two training videos (PPTs available as well) at Enhancing Peer Review, which has been expanded considerably:

Indeed, the Training & Communications Resources page has quite a number of valuable, well, you know, resources.

Have I looked at any of this yet? Hell no. Way too overstimulated. But I will most certainly mosey over soon and though yinz might want to sooner.

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