Archive for March, 2007

Canada Dispenses with Peer Review

All of you sweating to the paylines may want to look due north for respite. Science news reports that “several Canadian research institutes will receive multimillion-dollar grants from the government this year without having even asked for the money.

The government’s unprecedented decision to dispense with peer review in awarding the grants–or even solicit advice on which programs to fund–comes as a huge surprise to the science community, which has questioned the process even as it welcomes the windfall. “I feel like I’ve been adopted by a rich grandmother,” says David Colman, director of the Montreal Neurological Institute and Hospital, which will get nearly $13 million.”

Not surprisingly, “The biggest complaint from scientists is that national politicians and bureaucrats identified and targeted disciplines for investment, and then picked individual winners, without benefit of scientific input and peer review.”

On the other hand, the Canadian government boosted science & technology spending by 5%.

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Science in the Private Interest

Well – I spent the afternoon in research integrity heaven listening to exceptional plenary lectures on conflict of interest in biomedical research by Sheldon Krimsky (Tufts) and Catherine DeAngelis (JAMA editor). Both presentations were thoughtful and thought-provoking and delivered with delightful enthusiasm. Both noted with concern the rise of COI issues starting in the mid-80s and escalating to near daily headlines in current times. Read the rest of this entry »

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UVa Criticised for Tobacco Collaboration

From our friends across the Pond at BMJ:

University medical school accepts tobacco company funding

A string of medical experts have lined up to criticise the decision by the University of Virginia School of Medicine to accept funding for medical research from tobacco company Philip Morris—to the tune of $20m. Read the rest of this entry »

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Please Dehyphenate Your “-ly”-Endowed Adverbs

Not only does this quick grammar lesson keep the blog name honest, it addresses an increasingly common mistake I see in biomedical writing. Or should I say, “increasingly-common mistake” for effect. Yes, it’s true … a growing number of authors seem to think it looks proper to insert a hyphen between -ly adverbs (Ollie, Ollie, Ollie, get your adverb here!) and the word they modify.

Hyphenated modifiers never involve an -ly word. Ever. The suffix clearly identifies the -ly term as modifying the word following … no hyphen needed. So stop inserting the damn hyphen!

Okay, here’s the deal. Hyphens in compound modifiers help clarify which words go with which and which are descriptive versus part of the object being modified. In the absence of an -ly suffix, careful grouping & connection of words with hyphens is important to keep the meaning clear. A “well-hung (get your mind out of the gutter) portrait” could also be described as a “nicely hung portrait.” Longitudinally collected data could be long-term data.

With some lengthy scientific phrases, hyphen placement becomes critical for the meaning. For example: “small-molecule protein-protein interaction antagonist.” We have an antagonist. What kind of antagonist? Protein-protein interaction antagonist. What kind of protein-protein interaction antagonist? A small-molecule (not a small … pause for effect … molecule) protein-protein interaction antagonist. Make it overexpressed and upregulated, and you’ve got quite a party here.

Take home lesson: insert the hyphen where it is needed to clarify linkages among modifying words and distinguish these modifying words/phrases from the object they modify. Say the phrase slowly and see which words need to go together to best clarify the meaning for the reader.

Clear as mud? I thought so.

Maybe some day I’ll even get you folks to spell “Acknowledgment” correctly (using the preferred versus the generally accepted spelling, that is).

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Congressional Oversight of Misconduct Oversight

I’m not sure if Congressional involvement in a scientific misconduct case is necessarily good news, but I’m glad to see the matter isn’t being swept under the rug. The NYT reports that “A Congressional committee has asked Purdue University for copies of its findings in an investigation of a Purdue scientist who claims to have generated nuclear fusion in a desktop experiment.” The rationale? “In view of the billions of dollars the government spends on scientific research, Mr. Miller [Representative Brad Miller, NC-D, chair] said, ‘we need to know we are getting valid sound research and not research that is being manipulated. We’ve got to count on the integrity of their reviews,’ he added.” Read the rest of this entry »

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FY2004 Federal Science & Engineering Spending

I’m sure there is a reason for the lag in coming up with final dollar amounts for all these categories, but the NSF statistical folks have released their summary tables – data cut every which way – for FY04 S&E Support. You can see awards according to funding agency, type of activity, institution, historical trends, etc. These data are of most interest to those research administrators trying to make their institution look as good as possible on paper and to identify holes in their portfolios. But the grunts in the field may also be interested to look over the pecking order, albeit one a few years behind.

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Medical Payola

This morning’s NYT has an article summarizing new data about pharmaceutical industry payments to physicians in Minnesota -with such revelations now mandated by law and written up today (with data from Vermont as well) in JAMA. Not surprisingly, such an original contribution is accompanied by a sunshiney editorial. You might also appreciate the nice NYT graphic summarizing the “highlights” of pharm largess. Should anyone be surprised that a recent NYT/CBS news poll found that 85% of those queried believed it was “not acceptable” for doctors to be paid by drug companies to comment on prescription drugs and that such payments would influence the decisions that doctors made about patient care? And incredibly, at the same time we have accepting tobacco money being designated a form of academic freedom, we have drug companies referring to payments made to physicians as “trade secrets.” Read the rest of this entry »

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Promoting Integrity in Scientific Journals

I am still P30ing away but today attended an incredibly stimulating presentation-discussion on “balancing scholarship & entrepreneurship – issues in scientific technology transfer” … conflict of interest, conflict of commitment, scientist as scholar vs portfolio asset at major research universities. Great stuff. More later. For now, I wanted to alert you to a resource that was released during a time of major flux (for me) but should be noted here sooner than later: the Council of Biology Editors White Paper on Promoting Integrity in Scientific Journal Publications. This online & PDF document provides guidance to journal editors, reviewers, authors, and sponsors regarding their roles and responsibilities in safeguarding and advancing scientific knowledge. Nice material on the general media as well. These folks always do me proud. Anyway, more on the bigger issues raised today – right after I’ve signed a confidentiality agreement not to disclose any material related to the Center grant I’m currently overhauling …

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Eternal Sunshine of the Spotless Mind

Hmm. I can think of a few selective memories I’d like wiped from the banks … but I can think of more than a few govt agencies in whose hands this could be extremely worrisome:

A single, specific memory has been wiped from the brains of rats, leaving other recollections intact. Read the rest of this entry »

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Support Where You Need It Most

No, no – not *there*. In your grant application. I’m a bit P30-ed out right now, but am reminded in the course of this adventure to remind yuns the importance of solid letters of support, especially if they involve institutional commitment.

First and foremost, you do not want reviewers to be able to hold the stack of letters to the light & see all the paragraphs line up. Each letter must be unique (and yes, dear grant applicant, you will be ghosting these for the actual signatory) and convey specific details specific to that person/office/etc. And of course they are all delighted-enthusiastic-fully supportive of your proposed effort, which will clearly put you in the running for a trip to Stockholm in a decade or two.

These letters need to cite exactly how your work will benefit the institution, the signatory’s mission, the institution’s vision/strategic plan/related BS, and so on. Any well-defined personnel, funds, shared facilities, shared equipment, future recruits, new space, and so forth that can be promised on your behalf will be noted approvingly by reviewers.

The letter cannot say you will merely do good and avoid evil, though that would be a worthy course to take. The letter’s author must convey awareness and appreciation of your aims and approach and long-term impact locally and on public health (or state of science, for NSF and other non-PHS type proposals).

The signatory can brag about why she/he brings credibility to the effort and why his/her support should be of interest to the sponsor. If the letter writer will be working in a mentoring role, time to lay out all that past experience running a productive post-doc shop, um, I mean training environment, publishing with his/her trainees, nudging trainees onto get their own damn grants, etc.

And as always, please check the funding announcement in case any guidance is provided about what the study section will want to see in these letters (most often for center/program project/large cooperative type efforts and proposals that involve mentoring).

Ah, and if you plan to have the signatory commit some specific funds, space, or other tangible goodie, best to discuss this promised present in advance rather than have said signatory discover what he/she is expected to cough up when he/she reads the letter you’ve ghosted. They could get carried away by the moment & sign in a flushed flourish … but probably only with proper non-IRB-approved lubrication.

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