Archive for December, 2006

Science Breakthrough for 2006

I concur with Science’s tapping of the solving of the Poincaré conjecture as the scientific breakthrough of the year. I was fascinated to follow the story of Grigori Perelman in the NY Times. His dedication to the pure science rather than the spotlight makes him a hero in my book. I was saddened to read in the controversial New Yorker Magazine article that he was “retiring from mathematics, disenchanted by unspecified lapses in ‘ethical standards’ by colleagues.” The scientific community cannot afford to lose colleagues such as this.

I highly recommend a listen to the excellent reporting by NPR’s David Kestenbaum on Solving an Old Math Problem Nets Award, Trouble.

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NIMH Branch Chief Sentenced

I bet this guy started just by accepting those free lunches sponsored by pharmaceutical companies, thinking, what harm can there be?

‘Humbled’ scientist is put on probation
NIH’s Sunderland got funds from Pfizer
By Matthew Dolan (Baltimore Sun)

A leading government Alzheimer’s researcher told a federal judge in Baltimore yesterday that he had no good explanation for why he improperly accepted hundreds of thousands of dollars in undisclosed fees from a drug manufacturer while helping to control government-sponsored research with the same company. Read the rest of this entry »

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NIH Award Tracking Tool

This is a fantastic new Award Data Webtool that allows users to view a snapshot of NIH award data to individual institutions (searchable by name), including a breakdown by type of funding, by mechanism, by school, and by department. These data are all currently available in the Historic Ranking Information of the full Award Data Website, but you need to open individual files to get all the data for one institution. This is very convenient indeed. Data are available for FY2005, with FY2006 files “coming soon.” Of course, I can guarantee that the vice presidents/vice chancellors of research at major NIH-supported universities won’t be happy until these data are updated hourly …. What a nice present for the New Year from our poverty-stricken friends at the NIH!

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Fed R&D Budgets for FY05-07

From our statistically inclined friends at the NSF (lots of great statistical reports related to research spending, awards by institution, etc. – not just NSF … the whole pot of discretionary gold.

Federal Research and Development Funding by Budget Function: Fiscal Years 2005-07

Statistical Tables Only

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Peer-Reviewed Scientific Fraud

Probably not a big surprise that Science and Nature are closing out the year with commentaries on scientific fraud.

At Science, we have (instead of “Breakthrough of the Year”):

Breakdown of the Year: Scientific Fraud
Jennifer Couzin
Science 22 December 2006: Vol. 314. no. 5807, p. 1853

“Multiple inquiries discredited two papers Hwang published in Science in 2004 and 2005, which claimed some of the greatest accomplishments to date with human embryonic stem cells. The papers were retracted. But the scientific fraud, one of the most audacious ever committed, shattered the trust of many researchers and members of the public in scientific journals’ ability to catch instances of deliberate deception.

As it turned out, the Hwang debacle marked the beginning of a bad year for honest science. Incidents of publication fraud, if not on the rise, are garnering more attention, and the review process is under scrutiny.”

In Nature, we have humble pie … and a request for reader input and contribution to the peer-review process:

Peer review and fraud
Nature 444, 971-972 (21 December 2006) | doi:10.1038/444971b; Published online 21 December 2006

“Given the fact that cases of fraud demonstrably make it through refereeing processes, and given the importance of public trust in science, it proposes that journals apply additional scrutiny and risk assessment to papers that are likely to have a significant public impact, such as those with direct implications for policy, public health or climate change. The additional scrutiny recommended by the panel includes greater attention to raw data and a clarification of the contributions of each co-author.

Nature and the Nature research journals already encourage the specification of authors’ contributions to papers, and the uptake of this by authors has increased greatly in the past year — a fact that is welcomed by some funding agencies. We now intend to conduct a survey to help us decide whether to make this practice compulsory, and we would welcome readers’ feedback.

Another form of peer review emerges after publication, when work is replicated — or not. If this kind of discussion is to make it into the open, rather than be confined to gossip at conferences, it requires a forum where peers are able to comment on individual papers, with minimal editorial intervention. Would commenting on Nature papers be more widely adopted by researchers after they have been formally published than before? We intend to introduce this function next year, and find out.”

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State Healthcare/Research Ballot Initiatives

How long will Big Tobacco be allowed to keep making billions while inflicting morbidity and mortality on the same scale?

Modern Healthcare, Nov 13, 2006 v36 i45 p7
Tobacco taxes snuffed out. Read the rest of this entry »

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Unapproved Drug Promotion

This editorial in the NYT today dovetails nicely with the announcement at Henry Ford Health System that “Promotional products of any kind, food supplied by vendors or literature distributed by vendors, will no longer permitted at any Henry Ford site.”: Read the rest of this entry »

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Big Tobacco Buys Scientific Credibility

Hong MK, Bero LA. Tobacco industry sponsorship of a book and conflict of interest. Addiction. 2006 Aug;101(8):1202-11.

Aim: The tobacco industry has hidden its involvement in the design, conduct and publication of scientific research articles and has used the articles to argue against tobacco regulation. The objective of this study is to examine tobacco industry involvement in the development of scientific books. Read the rest of this entry »

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Dismissing Informed Consent

Special thanks to Dr. Huan Vu, a researcher in surgical oncology at Virginia Commonwealth University, for bringing to my attention this interesting commentary by Michael Crichton in the Wall St Journal (link to full commentary requires subscription for access). If medical centers can trample clinical trial volunteer rights so easily, we can only expect the current crisis in low recruitment rates to get worse. Read the rest of this entry »

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US Census Statistical Abstract

Well-written summary in the NYT this morning:

December 15, 2006

Fatter, Taller and Thirstier Americans
By SAM ROBERTS

Americans drank more than 23 gallons of bottled water per person in 2004 — about 10 times as much as in 1980. We consumed more than twice as much high fructose corn syrup per person as in 1980 and remained the fattest inhabitants of the planet, although Mexicans, Australians, Greeks, New Zealanders and Britons are not too far behind.

At the same time, Americans spent more of their lives than ever — about eight-and-a-half hours a day — watching television, using computers, listening to the radio, going to the movies or reading.

This eclectic portrait of the American people is drawn from the 1,376 tables in the Census Bureau’s 2007 Statistical Abstract of the United States, the annual feast for number crunchers that is being served up by the federal government today.

For the first time, the abstract quantifies same-sex sexual contacts (6 percent of men and 11.2 percent of women say they have had them) and learning disabilities (among population groups, American Indians were most likely to have been told that they have them)….

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